Modoc Cypress, Cupressus Bakeri Jeps., Does Occur in Modoc County

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Characterization of persistent Modoc viral infections in Syrian hamsters.

Adult Syrian hamsters were readily infected by intranasal inoculation with Modoc virus. Viremias were detected 2 to 6 days after infection and peak viremia titers (10(6.2) plaque-forming units/ml of blood) occurred 4 days postinoculation. All infected animals developed neutralizing and hemagglutination-inhibiting antibodies by 7 days, and complement-fixing antibodies by 14 days postinoculation....

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Modoc viral infections in the deer mouse Peromyscus maniculatus.

The pathogenesis of Modoc virus and its mechanism of transmission were investigated in Peromyscus maniculatus gambeli (deer mouse) as a model to understand the natural history of this virus. Animals were readily infected by the intranasal or subcutaneous route of inoculation. Virus could be detected by direct isolation techniques in many organs and body fluids during the first 7 to 9 days after...

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In vitro studies with Modoc virus in Vero cells: plaque assay and kinetics of growth, neutralization, and thermal inactivation.

A sensitive and quantitative assay system is described for plaquing Modoc virus in Vero cells. Neutralizing antibodies to Modoc virus could be detected by using this in vitro system by their interference with viral plaque formation. Virus was readily neutralized within 30 min at 37 C by a 1:10 dilution of hyperimmune hamster serum. The rate of neutralization and the total amount of virus neutra...

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Replacement of conserved or variable sequences of the mosquito-borne dengue virus 3' UTR with homologous sequences from Modoc virus does not change infectivity for mosquitoes.

The genus Flavivirus includes both vector-borne and no known vector (NKV) species, but the molecular determinants of transmission mode are not known. Conserved sequence differences between the two groups occur in 5' and 3' UTRs. To investigate the impact of these differences on transmission, chimeric genomes were generated, in which UTRs, UTRs+capsid, or the upper 3' UTR stem-loop of mosquito-b...

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ژورنال

عنوان ژورنال: Aliso

سال: 1965

ISSN: 2327-2929

DOI: 10.5642/aliso.19650601.06